.*: Mixed 400mg of Pediococcus product with 4ml of MRS broth, mixed thoroughly for rehydration, added 0.05mg/ml, 0.1mg/ml, 0.2mg/ml of Metronidazole, followed by incubating at 37 ⁰C for 4 hours, and plated 100 ul at 10,000 dilution (or 100,000 dilutions for control) onto MRS plate. The colony formation unit (cfu) was obtained after incubating the plates overnight at 37 ⁰C.

Antibiotics have become an integral part of treating any disorder/disease in today’s treatment methodology. The increase in number of prescribed antibiotics has not only caused reason for worry in terms of super-bugs, but more importantly has brought to light the disruption of the micro biota of the gastro-intestinal (GI) tract. The effect of antibiotics on natural gut microorganisms is a force to reckon with; especially because of the side-effects it causes which in turn weaken the horse. Some of the common effects are nausea, fever, loss of appetite and diarrhea.

 

While it is inadvisable to completely reduce the use of antibiotics, the cause of concern is also great. It has been proven that Pediococcus acidilactici, used as a probiotic along with Saccharomyces boulardii can help in alleviating the effects of the antibiotics in due course of treatment. This may appear counterintuitive due to the fact that antibiotics tend to limit the growth of microorganisms. Metrondiazole is used primarily to treat diseases or infections caused by anaerobic bacteria and protozoa thereby not disrupting completely the survival of the Pediococcus based probiotics. Also, the initial inoculum of Pediococcus acidilactici is very high (1 billion CFU) enabling it to survive at different concentrations of Metronidazole even up to 0.2 mg/ml, as shown in the picture above. This characteristic allows for Pediococcus acidilactici based probiotics to be used in conjunction with most of the antibiotics of the nitroimidazole family.

Up-coming article: Survival of Pediococcus acidilactici in presence of different classes of antibiotics!

  Survivability of MitoHorse^TM in Acidic Environment

          MitoHorse^TM probiotics are innovative nutritional supplements containing Pediococcus acidilactici. Compare to the microorganisms that are commonly used in probiotics such as Lactobacillus and Bifidobacterium, Pediococcus is much more suited to survive in the acidic environment of the horse's stomach and is able to reach the gastrointestinal tract with maximal efficiency.

 

             As you can see from the picture above, Lactobacillus is not as viable as Pediococcus since it can only survive at a pH of 6.2. Pediococcus on the other hand is viable at all of the pHs shown (6.2, 2.0, and 1.5). Normally the pH of the stomach is around 1.5 - 2.0, making it crucial that the probiotics are able to survive in low pH levels.

            Once the probiotic capsule makes its way through the stomach, its next stop is the small intestine where it helps maintain the proper balance of microorganisms found there. Often when the balance is disrupted, problems with digestion and excretion may result.

            A beneficial probiotic must be able to survive in the acidic environment of the stomach in order to reach the lower part of the gastrointestinal tract. Without this ability, efficiency is decreased. MitoHorse^TM is capable of surviving at a low pH, which makes it an effective probiotic!

Does your horse have problems eating

MitoHorse™  capsules?

Video insert: A happy pony, Frankie enjoys his daily dose of MitoHorse.



Are your horses ignorant of the nourishment stored in MitoHorse™  capsules? Is it possible that he/she doesn't want to eat those capsules? It is no reason to worry or think of ingenious ways to get them those 1 billion beneficial Pediococcus acidilactici and Saccharomyces yeast cultures served up through each of the MitoHorse™ capsules. It is rather easy if they eat up the capsules as they are, making life better for the two of you. Or else, there is always the way of opening the capsules and adding the powder within to their regular feed. 

However, why wouldn't they eat the capsules in the first place? 

MitoHorse™  capsules have sugar so as to keep the horses happy while they munch away at them. Here below is a video of a horse taking up his share of our probiotic supplements..

Mission Statement
To develop innovative technology and to produce novel nutraceutical products, which may serve as therapeutic and nutritional components, to improve and support human and animal health.


Who Are We 
Founded in 2003, Imagilin Technology is a biotechnology company located in Maryland, USA, specializing in innovative products and technology development for human and animal health and nutrition.

We focus on probiotics as an essential part of nutraceutical products to support  human and animal immune and digestive systems.

We have successfully introduced MitoMaxSUPER®, a patent-pending probiotic product  line for animals, to the pet industry and have established close distribution partnerships in North and South America, and Asia. We are a member of  American Pet Product Association and  a member of Pet Care Service Association. We recently developed and introduced to the market a new NutriLots™ probiotic line for humans and MitoHorse™ for equines as well.

The company has been comprehensively involved in basic research and clinical  studies worldwide for all of its products. The results of the research have been published in a number of scientific magazines and journals.

Imagilin has established collaborative research projects with the Walter Reed Army Institute of Research, the United States Department of Agriculture (USDA), ARS, Beltsville, the University of Maryland, and Hood College to further innovate in the development of new technologies and products.